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Biogerontology is the sub-field of gerontology concerned with the biological aging process, its evolutionary origins, and potential means to intervene in the process. The term "biogerontology" was coined by S. Rattan, and came in regular use with the start of the journal Biogerontology in 2000. It involves interdisciplinary research on the ...
Gerontology (/ ˌ dʒ ɛr ən ˈ t ɒ l ə dʒ i / JERR-ən-TOL-ə-jee) is the study of the social, cultural, psychological, cognitive, and biological aspects of aging.The word was coined by Ilya Ilyich Mechnikov in 1903, from the Greek γέρων (gérōn), meaning "old man", and -λογία (), meaning "study of".
Senescence ( / sɪˈnɛsəns /) or biological aging is the gradual deterioration of functional characteristics in living organisms. Whole organism senescence involves an increase in death rates and/or a decrease in fecundity with increasing age, at least in the later part of an organism's life cycle. [1] [2] However, the resulting effects of ...
Evolution of ageing. Appearance. hide. Enquiry into the evolution of ageing, or aging, aims to explain why a detrimental process such as ageing would evolve, and why there is so much variability in the lifespans of organisms. The classical theories of evolution ( mutation accumulation, antagonistic pleiotropy, and disposable soma) [1] [2] [3 ...
95-year-old woman holding a five-month-old boy. In the 21st century, researchers are only beginning to investigate the biological basis of ageing even in relatively simple and short-lived organisms, such as yeast. Little is known of mammalian ageing, in part due to the much longer lives of even small mammals, such as the mouse (around 3 years).
The free radical theory of aging states that organisms age because cells accumulate free radical damage over time. [1] A free radical is any atom or molecule that has a single unpaired electron in an outer shell. [2] While a few free radicals such as melanin are not chemically reactive, most biologically relevant free radicals are highly ...
The system theories include the immunologic approach to ageing, rate-of-living and the alterations in neuroendocrinal control mechanisms. (See homeostasis). Cellular theory of ageing can be categorized as telomere theory, free radical theory (free-radical theory of aging) and apoptosis. The stem cell theory of aging is also a sub-category of ...
The network theory of aging supports the idea that multiple connected processes contribute to the biology of aging. Kirkwood and Kowald helped to establish the first model of this kind by connecting theories and predicting specific mechanisms. In departure of investigating a single mechanistic cause or single molecules that lead to senescence ...
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