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Innate resistance to HIV. A small proportion of humans show partial or apparently complete innate resistance to HIV, the virus that causes AIDS. [1] The main mechanism is a mutation of the gene encoding CCR5, which acts as a co-receptor for HIV. It is estimated that the proportion of people with some form of resistance to HIV is under 10%.
HIV drug resistance occurs when microevolution causes virions to become tolerant to antiretroviral treatments (ART). ART can be used to successfully manage HIV infection, but a number of factors can contribute to the virus mutating and becoming resistant. Drug resistance occurs as bacterial or viral populations evolve to no longer respond to ...
Some people are resistant to certain strains of HIV. [49] For example, people with the CCR5-Δ32 mutation are resistant to infection by the R5 virus, as the mutation leaves HIV unable to bind to this co-receptor, reducing its ability to infect target cells. Sexual intercourse is the major mode of HIV transmission.
Resistance ranged from 3.9% to 8.6% and reached 19.6% among people who have received and transitioned to a dolutegravir-containing antiretroviral therapy (ART) regimen to combat high HIV viral loads.
Research to improve current treatments includes decreasing side effects of current drugs, further simplifying drug regimens to improve adherence, and determining better sequences of regimens to manage drug resistance. There are variations in the health community in recommendations on what treatment doctors should recommend for people with HIV.
Palm Springs, California, U.S. Known for. First person cured of HIV/AIDS. Timothy Ray Brown (March 11, 1966 [ 1] – September 29, 2020) was an American considered to be the first person cured of HIV/AIDS. [ 2][ 3] Brown was called "The Berlin Patient" at the 2008 Conference on Retroviruses and Opportunistic Infections, where his cure was first ...
Research shows that people without well working copies of CCR5 are either immune or resistant to HIV. The researchers’ goal for the trial was just that: To make babies who would never get HIV ...
August 23, 2013. (2013-08-23) (aged 66) New York City, U.S. Occupation. Artist. Stephen Lyon Crohn (September 5, 1946 – August 23, 2013) [1] also known as "The man who can't catch AIDS ", was a man notable for a genetic mutation, which caused him to be immune to AIDS. He was a great-nephew of Burrill Bernard Crohn, for whom Crohn's disease is ...