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Autoimmune inner ear disease. Autoimmune inner ear disease (AIED) was first defined by Dr. Brian McCabe in a landmark paper describing an autoimmune loss of hearing. [ 2] The disease results in progressive sensorineural hearing loss (SNHL) that acts bilaterally and asymmetrically, and sometimes affects an individual's vestibular system.
The inner ear (internal ear, auris interna) is the innermost part of the vertebrate ear. In vertebrates , the inner ear is mainly responsible for sound detection and balance. [ 1 ] In mammals , it consists of the bony labyrinth , a hollow cavity in the temporal bone of the skull with a system of passages comprising two main functional parts: [ 2 ]
Endolymphatic hydrops. Endolymphatic hydrops is a disorder of the inner ear. It consists of an excessive build-up of the endolymph fluid, which fills the hearing and balance structures of the inner ear. Endolymph fluid, which is partly regulated by the endolymph sac, flows through the inner ear and is critical to the function of all sensory ...
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Labyrinthitis. Labyrinthitis is inflammation of the labyrinth, a maze of fluid-filled channels in the inner ear. Vestibular neuritis is inflammation of the vestibular nerve (the nerve in the ear that sends messages related to motion and position to the brain). [ 2][ 3][ 4] Both conditions involve inflammation of the inner ear. [ 5]
Otitis media. Otitis media is a group of inflammatory diseases of the middle ear. [ 2] One of the two main types is acute otitis media ( AOM ), [ 3] an infection of rapid onset that usually presents with ear pain. [ 1] In young children this may result in pulling at the ear, increased crying, and poor sleep. [ 1]
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Rheumatology. Cogan syndrome (also Cogan's syndrome) is a rare disorder characterized by recurrent inflammation of the front of the eye (the cornea) and often fever, fatigue, and weight loss, episodes of vertigo (dizziness), tinnitus (ringing in the ears) and hearing loss. It can lead to deafness or blindness if untreated.