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Estrogen receptor (ER) positive. The cells of this type of breast cancer have receptors that allow them to use the hormone estrogen to grow. Treatment with anti-estrogen hormone (endocrine) therapy can block the growth of the cancer cells. Progesterone receptor (PR) positive.
Hormone receptor-positive (or hormone-positive) breast cancer cells have either estrogen (ER) or progesterone (PR) receptors or both. These breast cancers can be treated with hormone therapy drugs that lower estrogen levels or block estrogen receptors.
Estrogen receptor-positive breast cancer (ER+) happens when high levels of estrogen in breast cancer cells help cancer grow and spread. Finding out if cancerous cells have estrogen or progesterone receptors helps healthcare providers plan breast cancer treatment.
When breast cancer cells test positive for estrogen receptors, it’s called estrogen receptor-positive (ER-positive) breast cancer. It means that estrogen is fueling the growth...
Of the 250,000 new cases of breast cancer diagnosed in the United States each year, 70% are ER-positive, meaning their cells bear a receptor for the estrogen hormone, which drives the growth and proliferation of breast tumors.
People with ER-positive early breast cancers tend to have better survival than people with ER-negative early breast cancers [1]. As the studies below show, 5-year survival after diagnosis is about 10 percent better for women with ER-positive early breast cancer than for those with ER-negative early breast cancer.
The prevailing view of estrogen’s role in breast cancer is that it acts as a catalyst for cancer growth because it stimulates the division and proliferation of breast tissue, a process that carries the risk for cancer-causing mutations. The new work, however, shows that estrogen causes mischief in a far more direct manner.