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Apixaban. Apixaban, sold under the brand name Eliquis, is an anticoagulant medication used to treat and prevent blood clots and to prevent stroke in people with nonvalvular atrial fibrillation through directly inhibiting factor Xa. [ 6][ 7][ 8] It is used an alternative to warfarin to prevent blood clots following hip or knee replacement and in ...
Rivaroxaban, sold under the brand name Xarelto among others, is an anticoagulant medication (blood thinner) used to treat and prevent blood clots. [ 8] Specifically it is used to treat deep vein thrombosis and pulmonary emboli and prevent blood clots in atrial fibrillation and following hip or knee surgery. [ 8] It is taken by mouth.
The binding of apixaban to pockets S1 and S4 of Factor Xa. The pyrazole N-2 nitrogen atom of apixaban interacts with amino acid Gln-192 at the S4 pocket. The carbonyl oxygen interacts with Gly-216 of the S1 pocket as well as interacting with a water molecule. Apixaban binding to factor Xa
Bristol-Myers Squibb and Pfizer will provide additional information on the FDA approval of Eliquis in a separate press release, to be issued next week. About Bristol-Myers Squibb
The annual list price of Bristol Myers Squibb’s Eliquis, a blood thinner that reduces the risk of stroke, is $7,100 in the US. ... And the annual list price of Merck’s cancer drug Keytruda is ...
The Food and Drug Administration has granted approval for the next-generation anticlotting medication Eliquis, the regulator announced in a news release. The drug, administered in the form of a ...
Warfarin. Warfarin is an anticoagulant used as a medication under several brand names including Coumadin. [ 9] While the drug is described as a "blood thinner", it does not reduce viscosity but rather inhibits coagulation. Accordingly, it is commonly used to prevent blood clots in the circulatory system such as deep vein thrombosis and ...
Andexanet alfa, sold under the brand name Andexxa among others, is an antidote for the medications rivaroxaban and apixaban, when reversal of anticoagulation is needed due to uncontrolled bleeding. [8] It has not been found to be useful for other factor Xa inhibitors. [9] It is given by injection into a vein. [9]
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