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Apixaban. Apixaban, sold under the brand name Eliquis, is an anticoagulant medication used to treat and prevent blood clots and to prevent stroke in people with nonvalvular atrial fibrillation through directly inhibiting factor Xa. [6] [7] [8] Specifically, it is used to prevent blood clots following hip or knee replacement and in those with a ...
Medical use. Direct factor Xa inhibitors include rivaroxaban, apixaban and edoxaban, and are types of direct oral anticoagulant (DOAC), which are blood thinning drugs, one of the classes of antithrombotic drugs. [4] [5] [6] They are commonly prescribed to treat and prevent blood clots in veins, prevent stroke and embolism in people with non ...
Discovery and development of direct Xa inhibitors. Four drugs from the class of direct Xa inhibitors are marketed worldwide. Rivaroxaban (Xarelto) was the first approved FXa inhibitor to become commercially available in Europe and Canada in 2008. [1] The second one was apixaban (Eliquis), approved in Europe in 2011 [2] and in the United States ...
New Eliquis® (apixaban) Post-hoc Subanalysis of the Phase III ARISTOTLE trial Demonstrated that within 30 Days of a Procedure, Stroke or Systemic Embolism and Major Bleeding were Uncommon Results ...
These include Merck & Co's diabetes drug Januvia, big-selling blood thinner Eliquis from Bristol Myers Squibb and Pfizer, and AbbVie's leukemia treatment Imbruvica.
1. Thus, the CHA 2 DS 2 -VASc score is a refinement of CHADS 2[ 8][ 10] score and extends the latter by including additional common stroke risk factors, that is, age 65–74, female gender and vascular disease. [ 11] In the CHA 2 DS 2 -VASc score, 'age 75 and above' also has extra weight, with 2 points. The maximum CHADS 2 score is 6, whilst ...
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