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Vitamin D is a group of fat-soluble secosteroids responsible for increasing intestinal absorption of calcium, magnesium, and phosphate, and for many other biological effects. [ 1][ 2] In humans, the most important compounds in this group are vitamin D 3 ( cholecalciferol) and vitamin D 2 ( ergocalciferol ). [ 2][ 3] The major natural source of ...
Vitamin D deficiency is typically diagnosed by measuring the concentration of the 25-hydroxyvitamin D in the blood, which is the most accurate measure of stores of vitamin D in the body. [ 1][ 7][ 2] One nanogram per millilitre ( 1 ng/mL) is equivalent to 2.5 nanomoles per litre ( 2.5 nmol/L ). Severe deficiency: < 12 ng/mL = < 30 nmol/L[ 2 ...
003468. LOINC. 24322-0, 24323-8. The comprehensive metabolic panel, or chemical screen ( CMP; CPT code 80053), is a panel of 14 blood tests that serves as an initial broad medical screening tool. The CMP provides a rough check of kidney function, liver function, diabetic and parathyroid status, and electrolyte and fluid balance, but this type ...
Vitamin D toxicity. Cholecalciferol (shown above) and ergocalciferol are the two major forms of vitamin D. Specialty. Endocrinology, toxicology. Vitamin D toxicity, or hypervitaminosis D, is the toxic state of an excess of vitamin D. The normal range for blood concentration in adults is 20 to 50 nanograms per milliliter (ng/mL).
Calcitriol. Calcitriol is the active form of vitamin D, normally made in the kidney. [8] [9] [10] It is also known as 1,25-dihydroxycholecalciferol. It is a hormone which binds to and activates the vitamin D receptor in the nucleus of the cell, which then increases the expression of many genes. [11]
Michael F. Holick ( / ˈhɒlɪk / HOLL-ik; [1] born 1946) is an American adult endocrinologist, specializing in vitamin D, such as the identification of both calcidiol, the major circulating form of vitamin D, and calcitriol, the active form of vitamin D. His work has been the basis for diagnostic tests and therapies for vitamin D-related ...
Health effects of sunlight exposure. Exposing skin to the ultraviolet radiation in sunlight has both positive and negative health effects. On the positive side, exposure allows for the synthesis of vitamin D 3. Vitamin D has been suggested as having a wide range of positive health effects, which include strengthening bones [ 1] and possibly ...
Cholecalciferol is a form of vitamin D which is naturally synthesized in skin and functions as a pro-hormone, being converted to calcitriol. This is important for maintaining calcium levels and promoting bone health and development. [ 4] As a medication, cholecalciferol may be taken as a dietary supplement to prevent or to treat vitamin D ...
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