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Hydrocodone/ibuprofen ( INNs ), sold under the brand name Vicoprofen, is a fixed-dose combination analgesic medication used in short-term therapy to relieve severe pain. [ 3][ 4] Vicoprofen combines the analgesic and antitussive properties of hydrocodone with the analgesic, anti-inflammatory, and antipyretic properties of ibuprofen. [ 1]
Hydrocodone diversion and recreational use has escalated due to its opioid effects. [12] In 2009 and 2010, hydrocodone was the second most frequently encountered opioid in the pharmaceutical industry.
Hydrocodone is a highly selective full agonist of the μ-opioid receptor (MOR). [28] [54] [49] This is the main biological target of the endogenous opioid neuropeptide β-endorphin. [55] Hydrocodone has low affinity for the δ-opioid receptor (DOR) and the κ-opioid receptor (KOR), where it is an agonist similarly. [49]
Side effects. Main side effects of oxycodone [ 43] Two tablets (10 mg) of oxycodone and safety blisters. Most common side effects of oxycodone include reduced sensitivity to pain, delayed gastric emptying, euphoria, anxiolysis (a reduction in anxiety), feelings of relaxation, and respiratory depression. [ 44]
Acetaminophen is added to Vicodin to offset the side effects of hydrocodone. Depending on the specific formulation of Vicodin, it can contain 300 mg to 750 mg of acetaminophen and 2.5 mg to 10 mg ...
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v. t. e. An online pharmacy, internet pharmacy, or mail-order pharmacy is a pharmacy that operates over the Internet and sends orders to customers through mail, shipping companies, or online pharmacy web portal. Online pharmacies include: Pharmacy benefits managers – Entities that administer corporate prescription drug plans.
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