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Fenofibrate is a fibrate derivative, a prodrug comprising fenofibric acid linked to an isopropyl ester. It lowers lipid levels by activating peroxisome proliferator-activated receptor alpha (PPARα). PPARα activates lipoprotein lipase and reduces apoprotein CIII, which increases lipolysis and elimination of triglyceride-rich particles from plasma.
Fenofibrate is a peroxisome proliferator-activated receptor (PPAR) agonist. It activates a type of receptor called the peroxisome proliferator-activated receptor alpha, which is involved in breaking down fat from the diet, especially triglycerides.
Bezafibrate (marketed as Bezalip and various other brand names) is a fibrate drug used as a lipid-lowering agent to treat hyperlipidaemia. It helps to lower LDL cholesterol and triglyceride in the blood, and increase HDL . It was patented in 1971 and approved for medical use in 1978. [1]
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Ciprofibrate. Ciprofibrate is a fibrate that was developed as a lipid-lowering agent . It was patented in 1972 and approved for medical use in 1985. [1]
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Rank Drug Main indication Trade name 2018 sales (million USD) 2017 sales (million USD) 1 adalimumab: rheumatoid arthritis: Humira 19 936 18427 3 apixaban
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